Insect faeces were still considered one of the most advanced treatments for breast cancer up until the Middle Ages. At F. Hoffmann-La Roche Ltd (Roche), we are committed to protecting your personal information. And between the first quarter of 2017 and Q2 2022, CB Insights data shows WeRide raised $767 million in investment rounds involving U.S.-based venture capital firms. It is why sustainability is built into our business strategy and part of everyones job at Roche. All types of tests can help healthcare providers make more accurate diagnostics, support better management of individual patients and provide better guidance to manage population risk. Genentech's South San Francisco campus now serves as the headquarters for Roche pharmaceutical operations in the United States. In the Philippines, many patients were affected by a lockdown so strict initially that there was no transport for them to get to their care. Oktober in den verschiedenen Unternehmerkategorien fr den EY Entrepreneur Of The Year 2022 im Final steht. To succeed in Personalized Healthcare, this approach requires a holistic view of the entire healthcare delivery system. remember settings),Performance cookiesto measure the website's performance and improve your experience,Advertising/Targeting cookies, which are set by third parties with whom we execute advertising campaigns and allow us to provide you with advertisements relevant to you,Social media cookies, which allow you to share the content on this website on social media like Facebook and Twitter. Treffen Sie die EYewitnesses einer Welt im Wandel: In unserem Magazin #differentEYes teilen Vordenker:innen und Entscheidungstrger:innen ihre Ansichten zu wichtigen Themen. The WHO estimates that 311,000 women globally die each year from this disease, which is nearly 100% preventable with proper screening, vaccination and treatment. We use cookies to give you the best online experience. Respect for a healthy planet and the environment has always been a priority of our founding families and the company. DISCOVER MORE INSIGHTS. 50,000 Team Members; $9.4 billion 2021 Revenue; 60 Countries; JOIN US. Roche has been monitoring and actively minimising its environmental impact for many years while growing the business. It affects approximately one in 10,000 babies. march 26, 2021 bre1253754. Genentech became a member of the Roche Group in March of 2009. 1995-1998 Head Finance & Administration, Roche Brussels. SMA is a severe, progressive neuromuscular disease that can be fatal. Find jobs and learn more about exciting career opportunities at Roche, one of the world's leading research-based healthcare companies. Als Top CIO des Jahres werden ausgezeichnet: Hansruedi Born, CIO des Kantons Zrich, und Fabian Ringwald, CIO von SWICA. 2000-2004 Head Global Finance & Services, Roche Diagnostics, Basel. Was immer getan werden muss, um Ihr Unternehmen zu untersttzen wir stehen fr Sie bereit. For Roche, this is a commitment to continue operating our business responsibly, holistically and with a long-term perspective. Microsoft is quietly building a mobile Xbox store that will rely on Activision and King games. Huge progress has been made in recent years in breast cancer. Asking the better questions that unlock new answers to the working world's most complex issues. In 2018, Roche was recognised as Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry index of the Dow Jones Sustainability Indices for the tenth consecutive year. How we identify and meet those needs what we do every day must be sustainable if we are to succeed. Roche focuses on the science behind HPV, the known cause of almost all cases of cervical cancer, to help provide answers that aid clinical decision-making around patient care. Sustainability is integrated into Roches corporate vision, values, operating standards and guidelines. Driven by a passion and curiosity for science, we address some of the most urgent challenges in healthcare by developing tomorrows solutions. Today, and with the collaboration of Roche, the two enormous posters can be found hanging in just about every research institute from Argentina to New Zealand. Our commitment to sustainability stretches beyond our own business practices it also includes ensuring our suppliers approach to sustainability aligns with Roches. 2021. 2 of 3. By using our website you agree to our use of cookies in accordance with our cookie policy. Roche launched four new medicines, nine new molecules were moved to pivotal clinical studies, compared to about three per year during the last four years. We strive in all our activities to use natural resources wisely and improve energy efficiency. Our sustainability performance is included in our annual report, providing a holistic view of our business performance and reflecting the way we integrate sustainability in our operations. The demand for our newer medicines remains high.. Dr. Michal first compiled the Pathways Chart in 1965 and has been fine-tuning it ever since. We bring together extraordinary people, like you, to build a better working world. We will do our best to provide everyone who is in need with the appropriate information and support. This approach has proved influential in global sustainability policy development. For our analysis we follow the TCFD framework (Task Force on Climate-related Financial Disclosures). Sustainability is built into our business strategy and part of everyones job at Roche. Patients and science are at the heart of everything we do. All Rights Reserved. About Roche Throughout our 125-year history, Roche has grown into one of the worlds largest biotech companies, as well as a leading provider of in-vitro diagnostics and a global supplier of transformative innovative solutions across major disease areas. All Magrolimab Studies Re-Opening for Patient Enrollment in the U.S. Gilead Statement on WHO Recommendation of Veklury (Remdesivir) and Acceleration of Prequalification Submission, Gilead Implements Contract Pharmacy Integrity Initiative for Branded Hepatitis C Products, Gilead Expands Availability of Veklury (remdesivir) to Non-Hospital Outpatient Facilities, Gilead Announces Global Resolution of Bictegravir Patent Dispute with ViiV Healthcare, Gilead Announces Actions to Remove Counterfeit HIV Medications from US Supply Chain, Gilead Statement on Zydelig U.S. The International Agency for Research on Cancer recently concluded that women who worked night shifts for 30 years or more were twice as likely to develop breast cancer. Our goal is to achieve zero waste to landfill by 2035. Indem wir die Welt durch ihre Augen sehen und von ihren Erfahrungen lernen, gewinnen wir neue Perspektiven fr unsere eigene Reise. Taking innovative approaches, we could handover the medicine to the doctor in time to continue therapy. pays de la loire >> vende (85) As part of their merger agreement, Roche and Genentech combined their pharmaceutical operations in the United States. Minimising environmental impacts of our products throughout their lifecycle by developing and using circular solutions. Gilead Receives Complete Response Letter from U.S. FDA for Bulevirtide for the Treatment of Adults with Hepatitis Delta Virus, Gilead Continues Efforts to Halt the Distribution of Counterfeit HIV Medications and Protect Patient Safety, Veklury (Remdesivir) Demonstrates Continued In Vitro Antiviral Activity Against Omicron Subvariants, Including BA.4 and BA.5, Sacituzumab Govitecan-Hziy Trodelvy Elevated to Category 1 Preferred Recommendation in Second-Line Metastatic Triple-Negative Breast Cancer, Gilead Sciences Statement on FDA Acceptance of New Drug Application for Investigational Lenacapavir, Gilead Statement on U.S. Supreme Court Overturning Roe v. Wade. 2004-2006 Head Region Asia Pacific, Roche Diagnostics Singapore. On Wednesday, the U.K.s Competition and Markets Authority, one of three pivotal regulatory bodies arguably in a position to sink the acquisition, published a 76-page report detailing its review findings and justifying its decision last month to move its investigation into a more in-depth second phase. However, women who work nights are advised not to panic. Therefore, Roche started with Flexcare transport, thanks to which we were able to get patients from wherever they were to their doctor, to their care. In 2019 and 2021, CB Insights reported that Sinovation contributed to funding rounds totaling $292 million. Roche is the worlds largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Our sustainability performance is included in our annual report, providing a holistic view of our business performance and reflecting the way we integrate sustainability in our operations. People at Roche have focused relentlessly on doing everything possible to support the fight against COVID-19. The first record of a breast mastectomy was in A.D. 548 on Theodora, Empress of Byzantine. Roche records solid results for the first nine months of 2022, XProject & tackling inequalities in Women's Health. Further, partnering efforts provided access to four late-stage medicines. A Member of the Roche Group. October 19, 2022, Stories@Gilead - EY is a global leader in assurance, consulting, strategy and transactions, and tax services. In spite of the pandemic and the lockdown. Reporting in accordance with standards of the Global Reporting Initiative (GRI) ensures we conform to accepted reporting norms and meet the needs of all our stakeholders. In 2021, we freely distributed this invaluable scientific reference to >10,450 to students and educators in 100 countries. 5.0 out of 5 stars Not greasy or chalky! Protecting the environment is integral to our operations. If it werent for this treatment, I would not be here., Watch Evas storyLearn more about an often overlooked disease. Advancing Environmental Sustainability Serving Communities Through Philanthropy U.S. patients were provided access to our medicines at no cost through our patient assistance program in 2021. We can help mitigate and overcome todays most pressing environmental issues by setting realistic but ambitious goals and continuously measuring and monitoring our total environmental impact. Once I started to not be able to walk and my vision on my right eye deteriorated as well, I went to the ER., Watch Averys storyLearn more about the risk of NMOSD relapse. A total of 92 new molecular entities are in clinical development. 2004-2006 Head Region Asia Pacific, Roche Diagnostics Singapore. Sie knnen jederzeit auf Ihre vertrauten EY-Ansprechpartner zugehen und weitere Schritte und Manahmen fr Ihr Unternehmen besprechen. chalet and houses with land between murcia and alicante all of different prices and very good characteristics zones good views and close to all services all sale viewed by lawyer. A clear vision of achieving absolute zero greenhouse gas emissions by 2050 without compensating and off-setting emissions. Roche has been the main external sponsor of the Phelophepa healthcare trains for over 25 years. Our governance structure enables us to advance our sustainability agenda, ensuring close alignment with our business strategy while maintaining a close level of engagement with our external stakeholders. EY refers to the global organization, and may refer to one or more, of the member firms of Ernst & Young Global Limited, each of which is a separate legal entity. We engage regularly and systematically with our internal and external stakeholders to understand their needs and build mutual trust. In addition to the 5-year goals for 2015 - 2020, which are still ongoing, we have established the next set of 5-year goals for the years 2020 - 2025, including a 10-year ambition (2029) for a 50% reduction of our total environmental impact (eco-balance for operations and product stewardship score for products) and a goal to achieve real zero greenhouse gas emissions from scope 1 & 2 Protecting the health and safety of our people while enhancing their wellbeing is a top priority. Over Gileads 35-year history, bold ambitions were set and achieved in the companys fight against devastating diseases. provide an interface to an enzyme database like ExPASy ENZYME) we look forward to hearing from you. We prioritize minimizing our environmental impact and reducing our consumption of natural resources across all of our operations. Creating value for all stakeholders wherever they are, and competitive returns for investors who provide the capital to fund innovation. Were revolutionising personalised healthcare. All photography is for illustrative purposes only and all persons depicted are models. The Roche approach to personalised healthcare is rooted in a combination of advanced diagnostics, medicine, data, analytics, and digital technology, all with the goal of serving both patients and society at large. We depend on the contributions of our talented workforce who drive our progress while also providing opportunities to develop and grow. Roche has developed an open ecosystem for diabetes care that enables more meaningful interaction between people with diabetes and their physicians. Password requirements: 6 to 30 characters long; ASCII characters only (characters found on a standard US keyboard); must contain at least 4 different symbols; Ernst & Young Limited ist ein Schweizer Unternehmen mit Sitz in der Schweiz, das Dienstleistungen fr Kunden in der Schweiz erbringt. We seek to help counter the negative impacts of global warming by reducing our air and water emissions and continuously monitoring and managing our environmental impact. We are committed to reducing, reusing and recycling the waste generated throughout our operations. Cushman & Wakefield is committed to a sustainable future, achieving a balance between environmental, technological, economic and social objectives. We're working with organizations around the world to eliminate healthcare inequities and promote social justice. Reducing the effects of climate change is a pillar of our commitment to the environment. Sustainability is integrated into Roches corporate vision, values, operating standards and guidelines. The insights and quality services we deliver help build trust and confidence in the capital markets and in economies the world over. It can be used to make a wide range of products. In 2019 and 2021, CB Insights reported that Sinovation contributed to funding rounds totaling $292 million. Our people are at the heart of who we are. Go digital fast and empower your teams to work from anywhere. Nobody is exactly sure why this is. At EY, our purpose is building a better working world. Roche has established a multi-lingual global hotline (tel: +36 146 182 58; WhatsApp/SMS +36 707 177 394) and an email address (patientcare@roche.com) for patients and healthcare providers in or from Ukraine. Roche has established a multi-lingual global hotline (tel: +36 146 182 58; WhatsApp/SMS +36 707 177 394) and an email address (patientcare@roche.com) for patients and healthcare providers in or from Ukraine. Roche publishes its third quarter sales results. You may withdraw your consent to cookies at any time once you have entered the website through a link in the privacy policy, which you can find at the bottom of each page on the website. Our approach is holistic and integrates the three dimensions of sustainability. Significant progress in our understanding and treatment of breast cancer in recent decades has seen a dramatic reduction in the use of radical mastectomy (where the breast, underlying chest muscle and lymph nodes are removed), which was the standard surgical approach to breast cancer right up until the 1960s. On this weeks podcast, we discuss the knock-on impact covid has had on staffing and services, after medical consultants at a major acute trust warned its leadership that specialist staff shortages are causing services to become unsafe. new molecular entities in clinical development, Patient whose physician used genomic testing to find a targeted treatment for her lung cancer. VIEW THE ANNUAL REPORT. Cushman & Wakefield is committed to a sustainable future, achieving a balance between environmental, technological, economic and social objectives. Neuromyelitis optica spectrum disorder (NMOSD) and spinal muscular atrophy (SMA) are two examples. It is through stories of hope, innovation, collaboration and medical breakthroughs that we truly measure the reach and impact of our work. La deuxime usine amricaine de ROCKWOOL commence sa production commerciale La roche est notre principale matire premire et le fondement sur lequel repose notre activit. In addition to cookies that are strictly necessary to operate this website, we use the following types of cookies to improve your experience and our services:Functional cookiesto enhance your experience (e.g. Steffen et al. Neuroscience is a major focus of R&D at Roche. Our goal is to reduce complexity while optimising therapy. With physicians and their staff at higher risk of exposure to the virus while on site at the hospital or laboratory, digital pathology that enables remote diagnoses has emerged as a vital technology. Please refer to your advisors for specific advice. This approach means no single department is responsible for managing sustainability. Review ourcookie policyfor more information. Cushman & Wakefield. Klicken Sie auf Explore,um zu unserer englischsprachigen bersicht zu gelangen und sich zu registrieren. 2021-09-23T13:32:00+01:00. We prioritise employee safety, health and development, while encouraging a workplace environment that embraces inclusion, integrity, mutual respect and equal opportunities for all. Gilead Sciences Statement on Recent Events in Washington, D.C. Gilead Announces New Arm of HIV Womens Prevention Study to Evaluate the Investigational Long-Acting HIV-1 Capsid Inhibitor Lenacapavir in Addition to Descovy for PrEP, Gilead Sciences Statement on The World Health Organizations Updated Veklury (Remdesivir) COVID-19 Treatment Guidelines, Gilead and Kite Oncology Demonstrate Transformative Impact of Cell Therapy and Promise of Blood Cancer Portfolio at ASH 2022, U.S. Food and Drug Administration Approves Vemlidy (tenofovir alafenamide) for Treatment of Chronic Hepatitis B Virus Infection in Pediatric Patients. We respect and support the human rights of every person we reach and ensure they are rigorously embedded into every aspect of our business. real estate >> real estate sale. There is a growing variety and availability of tests related to SARS-CoV-2. The left breast is 5 - 10% more likely to develop cancer than the right breast. Our goal is to pursue groundbreaking science to develop new treatments that help improve the lives of people with potentially devastating diseases. The same goes for climate change, where we want to reduce our environmental impact by half over the next decade. And between the first quarter of 2017 and Q2 2022, CB Insights data shows WeRide raised $767 million in investment rounds involving U.S.-based venture capital firms. Significant progress in our understanding and treatment of breast cancer in recent decades has seen a dramatic reduction in the use of radical mastectomy (where the breast, underlying chest muscle and lymph nodes are removed), which was the standard surgical approach to breast The first record of a breast mastectomy was in A.D. 548 on Theodora, Empress of Byzantine. Because we care about science and scientists, the charts can now be accessed as an interactive online service with additional features. We seek to minimise the health, safety, and environmental impact of our products, services, and devices. Hemp, or industrial hemp, is a botanical class of Cannabis sativa cultivars grown specifically for industrial or medicinal use. November 02, 2022, Stories@Gilead - Please be aware that we do not take any responsibility for accessing such information which may not comply with any legal process, regulation, registration or usage in the country of your origin. The spread of COVID-19 has added an element of actual physical danger to the practice of pathology. ZRICH, 8. 07 juil. Its worth noting that no link was found between higher breast cancer risk and periods of night work which were shorter than 30 years. Insgesamt 43 Unternehmen haben sich 2022 fr dieses Programm beworben, nun hat die unabhngige Jury entschieden, wer am 28. Privacy Notice. We develop outstanding leaders who team to deliver on our promises to all of our stakeholders. CareersDigitalPurposeTrustGrowthTaxFinancial ServicesCOVID-19. Enabled by data and technology, our services and solutions provide trust through assurance and help clients transform, grow and operate. The insights and services we provide help to create long-term value for clients, people and society, and to build trust in the capital markets. By continuously engaging with policy makers, we ensure Roche creates long-term impact not only for patients, but society as a whole. Lifelong nuns, like all women who never have children, are at an increased risk of dying from breast, ovarian and uterine cancers, compared with mothers. Roche is investigating more than a dozen medicines for various diseases of the CNS. Dr. Gerhard Michal the author and creator of our brilliant Biochemical Pathways poster discusses his lifes work. Our anniversary year was no exception: In 2021 our more than 100,000 employees and our partners developed, manufactured and provided global access to state-of-the-art diagnostics and treatments for serious diseases, particularly for A Roche cancer medicine paired with a Roche companion diagnostic testand the powerful collaboration between the Roche Diagnostics and Roche Pharmaceuticals teams that delivered both to the markethave brought new hope to patients like Eva who are diagnosed with triple-negative breast cancer. Along with bamboo, hemp is among the fastest growing plants on Earth. provide an updated and extended analysis of the PB framework. Diese haben oftmals erheblichen Einfluss auf die Vertragsgestaltung sowie den Kaufpreis. When the availability of personalised care increases, both individual patients and society benefit. Reviewed in the United States on October 17, 2022. About Roche Throughout our 125-year history, Roche has grown into one of the worlds largest biotech companies, as well as a leading provider of in-vitro diagnostics and a global supplier of transformative innovative solutions across major disease areas. A Member of the Roche Group. Genentech's South San Francisco campus now serves as the headquarters for Roche pharmaceutical operations in the United States. EY Global hat mgliche Optionen zur strategischen Fortentwicklung seiner Geschftsbereiche analysiert und die Entscheidung getroffen, der Partnerschaft den Vorschlag zur Aufspaltung in zwei getrennte, multi-disziplinre Organisationen zu unterbreiten. Results and Presentations. If you think you could contribute or collaborate with us (e.g. Trainee at Corporate Finance, Roche Basel. This material has been prepared for general informational purposes only and is not intended to be relied upon as accounting, tax, or other professional advice. Develop scalable, custom business apps with low-code development or give your teams the tools to build with services and APIs. Commenting on the results, CEO Severin Schwan commented: Group sales grew 2% despite the expected sharp decline in COVID-19-related products in both divisions. The left side of the body is also roughly 5% more prone to melanoma (a type of skin cancer). Sustainability Report 2020 Notre approche de la durabilit Tlchargez notre rapport 2020 Press Release. We are dedicated to making a lasting impact on society by building stronger and healthier communities. The insights from Comprehensive Genomic Profiling (CGP) help physicians refine their diagnosis, and provide prognostic information as well as predictive insights to each individual. Indication for Follicular Lymphoma and Small Lymphocytic Leukemia, Veklury (Remdesivir) Receives Positive CHMP Opinion for the Treatment of Adults Not on Supplemental Oxygen and Considered High Risk for COVID-19 Disease Progression, Gilead Issues a Voluntary Nationwide Recall of Two Lots of Veklury (Remdesivir) Due to Presence of Glass Particulates, Gilead Statement on Veklury (Remdesivir) and the SARS-CoV-2 Omicron Variant, Gilead and Merck Announce Temporary Pause in Enrollment for Phase 2 Study Evaluating an Oral Weekly Combination Regimen of Investigational Islatravir and Investigational Lenacapavir, Gilead Announces Decision Not to Pursue Marketing Authorization for Descovy for Pre-Exposure Prophylaxis in the European Union, Gilead Statement on New NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Recommendation for Sacituzumab Govitecan-Hziy (Trodelvy) in Second-Line and Later Metastatic Triple-Negative Breast Cancer, Gilead Sciences Statement on Requiring Vaccination Against COVID-19 for Employees, Gilead Warns of Counterfeit HIV Medication Being Distributed in the United States, Gilead Sciences Statement on Positive Phase 3 AMBITION Study Findings for the Treatment of HIV-Associated Cryptococcal Meningitis, Gilead Sciences Response to Open Letter Regarding Access to AmBisome (liposomal amphotericin B), Gilead Statement on New England Journal of Medicine Publication of Positive Phase 3 ASCENT Study of Trodelvy in Metastatic Triple-Negative Breast Cancer, Gilead Sciences Statement on Phase 3 Veklury (Remdesivir) Intravenous Study in High Risk Non-Hospitalized Patients with COVID-19, Gilead Announces Additional Updates to The Advancing ACCESS Patient Assistance/Medication Assistance Program, Gilead Announces Updates to The Advancing ACCESS Patient Assistance/Medication Assistance Program, Gilead Announces Plans for New Location in North Carolinas Research Triangle Region Dedicated to Business Services, Gilead Sciences Statement on the Passing of the Honorable George P. Shultz, PhD. Sustainability Matters in Commercial Real Estate. Our procurement goals and performance align with the Roche Group Strategy and ensure the sustainable supply of medicines and diagnostics to our patients. provide an updated and extended analysis of the PB framework. Since the founding of our company, we have been developing innovative solutions for a wide range of chronic and life threatening health conditions that continue to revolutionise healthcare. NMOSD is a rare and debilitating autoimmune condition of the CNS, causing blindness, muscle weakness and paralysis. Teams worked nonstop to ensure continued supplies of existing products or the development of urgently needed new tests and medicines. EY | Assurance | Consulting | Strategy and Transactions | Tax. One of our top priorities remains lowering our air emissions and water contamination and reaching absolute zero greenhouse gas emissions by 2050. It is more common in dogs than cats, but tends to be more aggressive in cats than dogs. This website contains information on products which is targeted to a wide range of audiences and could contain product details or information otherwise not accessible or valid in your country. *All growth rates in this report are at constant exchange rates (CER; average 2019). At Roche, we recognise a safe workplace as a human right, and are committed to preventing and mitigating identified risks. Our sustainability performance is included in our annual report, providing a holistic view of our business performance and reflecting the way we integrate sustainability in our operations. Password requirements: 6 to 30 characters long; ASCII characters only (characters found on a standard US keyboard); must contain at least 4 different symbols; For many years, personalised healthcare meant testing for a disease-related biomarker and providing a targeted treatment. FDA approvals for three additional companion diagnostic indications followed: advanced ovarian, breast and non-small cell lung cancer. It is through stories of hope, innovation, collaboration and medical breakthroughs that we truly measure the reach and impact of our work. Our approach to increasing access to healthcare ensures our life-changing solutions reach people around the world. For Roche, this is a commitment to continue operating our business responsibly, holistically and with a long-term perspective. pays de la loire >> vende (85) We contribute to a better society by enabling the right treatment for the right patient at the right time for the right value. For more information about our organization, please visit ey.com. The doctor passed on the message to the Roche team. XProject is our long-term commitment to drive meaningful change through partnerships, funding and action to help close the gaps in womens health for better health outcomes for everyone. Finden Sie heraus wie Nachhaltigkeit und die Pandemie den Immobilienmarkt prgen: Lesen Sie auf unserer englischsprachigen Webseite, wie wir uns rund um den Globus engagieren, um die Zukunft mitzugestalten und langfristigen Wert fr unsere Kunden, unsere Mitarbeiter und die Gesellschaft zu schaffen. 92% of waste diverted from landfills in 2021. This website contains information on products which is targeted to a wide range of audiences and could contain product details or information otherwise not accessible or valid in your country. The solidarity and community we experience now in the fight against COVID-19 will significantly increase our collaboration, and there is no doubt that we will come out of this even stronger. At Gilead, we strive to transform and simplify care for people with life-threatening diseases around the world. Transparency and accountability are essential to maintain trust and fulfil our purpose. 2020 EYGM Limited. #Better Questions - wir stellen die richtigen Fragen, COVID-19: Untersttzung in unsicheren Zeiten, Explore Transactions and corporate finance, Climate change and sustainability services, ESG Governance, Risk Management and Compliance, Sustainable Products and Circular Economy, Praxisnderung im Kanton Genf zur Vermeidung der Mehrfachbesteuerung von Grundstckgewinnen (Step-Up). 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