Follow your doctor's dosing instructions very carefully. All You Need To Know! Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. This could cause an allergic reaction if you have a latex allergy. To learn more about how often this side effect occurred, see the drug's prescribing information. For the triple end point of risk of cardiovascular death, MI, and stroke, the HRs were 0.82 (P = .0021) for those with diabetes taking evolocumab and 0.78 (P = .0002) for those without diabetes . But if they continue for more than 2 weeks immediately consult your doctor and seek help. Keep in mind, though, that joint pain can be a symptom of other Repatha side effects, such as fatigue and flu. Talk with your doctor if you have severe or persistent diarrhea. Learn how liver damage can affect cholesterol and what treatments you can explore. Dr started paper work for Repatha insurance accepeted been on Repatha for 2 months so far no side effects. As with most drugs, you may have some side effects from Repatha. A possible explanation of the discrepancy is that the deficiency of . * If left untreated, diabetes can cause damage to the eyes, heart, and kidneys. If not treated, high blood sugar and diabetes can lead to serious complications over time, including kidney or eye disease and nerve damage. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. The needle covers on the single-dose prefilled syringes and the inside of the needle caps on the single-dose prefilled SureClick autoinjectors contain dry natural rubber. What Happens If You Forget To Take Your Cholesterol Medicine? Healthline Media does not provide medical advice, diagnosis, or treatment. Severe high blood pressure may cause symptoms such as: Most commonly, high blood pressure is discovered through a blood pressure reading. Other drugs that have the same active ingredients (e.g. 112,588 people reported to have side effects when taking Repatha. Reasons And Relief! You can use the study as a second opinion to make health care decisions. For common cholesterol-related diseases, a single dose is given once a month. They can then use this information to adjust your treatment plan if needed. This document does not contain all possible side effects and others may occur. Randomized controlled trials with anti-PCSK9 MAbs however showed no effect on the risk. The phase IV clinical study analyzes which people take Repatha and have Type 2 diabetes. These are not all the possible side effects of Repatha. All information is observation-only. No, the side effects of Repatha SureClick injections should be the same as those for the prefilled syringes and the Pushtronex device. See the drugs prescribing information for details. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. It is often used in high blood cholesterol. Dosage of drugs is not considered in the study. Depending on your dose amount, you may need to use up to 3 separate injections at one time. 2022 eHealthMe.com. They can try to determine the cause of your symptoms and help you find ways to manage them. Repatha mainly contains an active drug called evolocumab. Health Conditions Besides side effects as above, repatha side effects also have a serious and dangerous. There are two types of cholesterol: LDL and HDL. Type-2-diabetes Repatha and Type 2 diabetes - a phase IV clinical study of FDA data Summary: Type 2 diabetes is found among people who take Repatha, especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Other drugs that have the same active ingredients (e.g. Also, diabetes and increased blood sugar levels are rare side effects of Repatha. Allergic reaction. It is not safer to take Repatha if you are diabetic. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. You can use the study as a second opinion to make health care decisions. This is especially helpful when you first start taking new drugs or using a combination of treatments. Learn about side effects, cost, dosage, and more for Repatha (evolocumab). You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Stop taking Repatha and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms. including neurocognitive events and new onset diabetes, compared to patients treated with Repatha or placebo who always . Here's how. How Should I Manage My Hereditary High Cholesterol? Repatha (evolocumab) is a human monoclonal immunoglobulin G2 (IgG2) used along with diet, exercise and maximum tolerated doses of statins to reduce LDL cholesterol in adults with heterozygous familial hypercholesterolemia (and inherited disorder that causes high levels of LDL) or adults with heart problems related to excess cholesterol in the body. Atherosclerosis and arteriosclerosis are often confused with each other, but theyre different conditions. The study uses data from the FDA. It is created by eHealthMe based on reports of 100,050 people who have side effects when taking Repatha from the FDA, and is updated regularly. Repatha responds very quickly. If you use Repatha during pregnancy, your doctor will likely provide information regarding the Repatha pregnancy safety study. They can discuss potential side effects with you and ways to manage them. Repatha is a medication prescribed by doctors for patients having heart-related diseases. Symptoms of increased blood sugar include: Its important to let your doctor know if you have any of these symptoms with Repatha. What are the possible side effects of Repatha? Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. And their major effects are liver damage, increased blood glucose levels, higher risk of type 2 diabetes, cognitive (mental) problems, and muscle damage leading to rhabdomyolysis. 2022 eHealthMe.com. If your doctor confirms youve had a serious allergic reaction to Repatha, they may have you switch to a different treatment. The most common side effects of Repatha include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site. Repatha comes in a solution form. Save my name, email, and website in this browser for the next time I comment. Almost 90 % of those who took Repatha experienced increased blood sugar levels. Its a prescription drug used to: If you and your doctor agree that Repatha is safe and effective for you, youll likely use it long term. There arent enough studies to know if Repatha is safe to use during pregnancy or while breastfeeding. Like most drugs, Repatha can cause an allergic reaction in some people. Remember to monitor your blood sugar level before and after taking Repatha. All product names, logos, brands, trademarks and registered trademarks are property of their respective owners. If youre pregnant or planning a pregnancy, or are breastfeeding or considering it, talk with your doctor. The use of the eHealthMe site and its content is at your own risk. If your doctor determines that you have high blood sugar, theyll likely recommend treatment options to manage your blood sugar level. After 4 months constant muscle and joint pain in knees, hips, shoulders, wrists. To reduce your risk of an injection site reaction, try to inject Repatha in a different location each time you use it. Liver-related side effects were not reported in studies of Repatha. Repatha is one of the most recommended and effective drugs to prevent cardiovascular events. Below are answers to some frequently asked questions about Repathas side effects. Repatha has active ingredients of evolocumab. It comes in three forms: For more information about Repatha, including details about its uses, see this in-depth article. Its not known whether Repatha passes through breast milk or how it could affect a child who is breastfed. The most common side effects of Repatha include Runny nose Sore throat Symptoms of the common cold Flu or flu-like symptoms Back pain High blood sugar levels (diabetes) Redness, pain, or bruising at the injection site Tell your doctor if you have any side effect that bothers you or that does not go away. You can inject Repatha into your belly, thigh, or upper arm. Call your doctor the right way if you develop these conditions. These factors include your insurance plans. Symptoms of severe allergic reactions include swelling under your skin, eyelids, lips, hands, and feet. Increased blood sugar might lead to diabetes. Does Repatha cause any long-term side effects? The study uses data from the FDA. Learn more about some of the side effects Repatha may cause. Our website services, content, and products are for informational purposes only. Be sure to tell your doctor if you have a latex or rubber allergy so they can prescribe a safe form of Repatha for you. Repatha may not be right for you if you have certain medical conditions. Stop taking Repatha and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms. 06/22, These are not all the possible side effects of, You are encouraged to report negative side effects of prescription drugs to the FDA. So, tell your doctor if you experience any effects and reactions like allergy signs. Despite the need and recommendations to lower lipid levels in patients with diabetes, the ADA acknowledges that statin and PCKS9 inhibitor therapy can cause a modest increase in incident diabetes. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. We study millions of patients and 5,000 more each day. For example, statin drugs such as Lipitor (atorvastatin) and Crestor (rosuvastatin) may cause certain liver problems. The most common side effects of Repatha include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site. Evolocumab is a monoclonal antibody designed to prevent stroke and heart attack. Talk with your doctor if you have joint pain thats not relieved by OTC medications. There's a new diabetes drug on the market and doctors just love a new drug. In clinical trials with more than 26,000 patients, Repatha demonstrated a consistent safety profile. The phase IV clinical study analyzes which people take Repatha and have Back pain. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Repatha, however, is FDA approved to treat high LDL-cholesterol levels in children aged 10 years and older. In a recent study, people having higher cholesterol levels conceived this drug to prevent stroke and heart attack. It is created by eHealthMe based on reports of 100,050 people who have side effects when taking Repatha from the FDA, and is updated regularly. Probably not. Diarrhea was a common side effect reported in studies of people using Repatha. If you have certain heart conditions, your doctor might suggest Repatha as a treatment option. But check with your doctor or pharmacist before taking OTC drugs to be sure theyre safe for you. What are the serious side effects of Repatha? Among the 16,676 patients without diabetes mellitus at baseline, the incidence of new-onset diabetes mellitus during the trial was 8.1% in patients treated with Repatha compared with 7.7% in . The active ingredient in Repatha is evolocumab. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. The most common kinds of reactions reported in Repathas studies were discoloration, pain, and bruising at the injection site. You can use the study as a second opinion to make health care decisions. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Signs Of High Blood Sugar definition of fasting blood sugar, low cut diabetic socks What Causes Diabetes Fasting Blood Sugar. These side effects can vary depending on what condition the drug is being used to treat. With medical big data and AI algorithms . diabetes ; high blood pressure ; If experienced, these tend to have a Less Severe expression i ; inflammation of the tissue lining the sinuses ; inflammation of the lining of the stomach and . If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. (6) Flu, dizziness, and abdominal pain. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. In some cases, weight gain can be a symptom of these side effects. single-dose prefilled auto-injector called SureClick, single-dose prefilled cartridge in the Pushtronex system, which you wear on your body, increased urgency to have a bowel movement, swelling under your skin, usually in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, an antihistamine you take by mouth, such as, a product you apply to your skin, such as hydrocortisone cream, what dose of the drug you were taking when you had the side effect, how soon you had the side effect after starting that dose, any other information you feel is important. Talk with your doctor before starting Repatha. All information is observation-only. Does High Cholesterol Cause Heart Disease? Type 2 diabetes is found among people who take Repatha, especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months. For example, hair loss is a rare side effect of cholesterol-lowering drugs called statins, which include: If your doctor prescribes a statin along with Repatha to lower your cholesterol, you may have hair loss from the statin. Symptoms of high blood sugar can include: Its important to tell your doctor right away if you have symptoms of high blood sugar while using Repatha. Cholesterol-Lowering Statins: Do They Help With COVID-19? But some side effects can be more serious and require medical attention. Our phase IV clinical studies alone cannot establish cause-effect relationship. Talk with your doctor about your health history before starting this drug. "Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Many of the drugs common side effects are mild and can be managed at home. Below are a few of the more common side effects reported by people who took Repatha in studies. PCSK9-inhibiting drugs are showing promise as an alternative treatment for high cholesterol. Repatha is usually a long-term treatment. Serious side effects arent common. Below are some factors to consider. In past years many patients have survived strokes and attacks after taking Repatha. Repatha may cause mild side effects other than those listed above. Repatha has active ingredients of evolocumab. Started Repatha in November 2021, some minor aches. The most common side effects of Repatha include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site. Repatha may cause raised blood sugar levels. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Having too much LDL cholesterol can put you at greater risk of heart attack or stroke. Cholesterol ran between 180 and 230 started at about 320. If your blood pressure is high, they may prescribe medication to manage it. Theyll likely have you check your blood pressure regularly and recommend ways to manage it. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. We have to use injections to apply for the medicine. Especially when it's packaged with plenty of hype like this one. because of their greater baseline risk of cardiovascular events, patients with diabetes tended to have a greater absolute risk reduction with repatha treatment than patients without diabetes (2.7 percent [95 percent ci, 0.7-4.8] versus 1.6 percent [95 percent ci, 0.1-3.2]), driven largely by a greater absolute risk reduction in coronary If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. I inject every 2 weeks. It is based on evolocumab (the active ingredients of Repatha) and Repatha (the brand name). If you develop any side effects as mentioned below immediately consult your doctor. You can then share this information with your doctor. Like other drugs, Repatha can cause mild to serious side effects (also called adverse effects). And some may be easily managed. But these side effects are not caused by Repatha. It should be safe to drink alcohol during Repatha treatment. The liver produces and clears cholesterol in the body. The dosage will be given according to the doctors prescription. It can cause kidney failure, eye disease, and nerve damage. As you can see in the chart above, although it can cause high blood sugar (diabetes) most of the other common side effects are relatively mild. More common side effects in people using Repatha to lower cholesterol levels include: More common side effects in people using Repatha to reduce the risk of heart attack, stroke, and certain heart surgeries include: *To learn more about this side effect, see the Side effects explained section below. Read on to, Cholesterol is a risk factor for heart disease, but recent research suggests the connection may be more complex than just limiting dietary cholesterol. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. Other factors may also affect whether Repatha is a good treatment option for you. It might even cause a risk of death. Using Repatha can enhance blood sugar levels in your body. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 4 people, 8.51% Diabetes: 4 people, 8.51% Type 2 Diabetes: 3 people, 6.38% Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 6.38% Back Pain: 2 people, 4.26% Cardiac Failure Chronic: 2 people, 4.26% Chest Pain: 2 people, 4.26% In a recent study, people having higher cholesterol levels conceived this drug to prevent stroke and heart attack. 420 mg by subcutaneous injection once a month. Different individuals may respond to medication in different ways. It's available as prefilled, single-dose: syringes SureClick autoinjectors, which deliver doses over 15 seconds Pushtronex systems,. Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. What does Repatha do? If your doctor prescribes a statin along with Repatha to lower your cholesterol, you may have hair loss from the statin. Tell your doctor if you have any side effect that bothers you or that does not go away. Most common side effects of Repatha are mild. Talk with your doctor or pharmacist to learn more about ways to reduce your risk of side effects with Repatha. You can learn more about how we ensure our content is accurate and current by reading our. Does Repatha Cause Diabetes? It's possible that having high blood sugar could lead to diabetes. People will also experience allergic reactions as another side effect. Common medications used to lower cholesterol may reduce the severity of COVID-19 and the risk of dying from this disease, a preliminary study suggests. Patients having diabetes will also experience the following conditions: It is essential to inform your doctor if you show any symptoms of high blood sugar levels. And this could cause long-term issues such as vision loss, heart disease, and kidney failure . For example, Repatha may cause changes in your blood sugar level, possibly leading to diabetes . You can also try resting the painful joints or applying an ice pack. Repatha will soon work after receiving the first dosage. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. The most common side effects of Repatha include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site. This side effect was not reported by people using Repatha to lower cholesterol. But if you have any symptoms that are ongoing or bother you, talk with your doctor or pharmacist. (This is known as a drug-condition interaction.). The Repatha Pushtronex system does not contain rubber or latex, so may be a safer option for you. Just days ago, a Reuters report gushed about Ozempic (generic name: semaglutide), which won FDA approval for treating diabetes in December of 2017. Talk with your doctor if you have any of these symptoms and think you may have high blood pressure. However, certain side effects of Repatha could lead to long-term problems. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Among them, 380 people (0.34%) have Diabetes. Symptoms can include: Mild diarrhea can usually be relieved with OTC treatments, such as Imodium-AD (loperamide). Check whether Type 2 diabetes is associated with a drug or a condition, Type 2 diabetes and drugs with ingredients of evolocumab, Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat), Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires), Arthritis (form of joint disorder that involves inflammation of one or more joints), Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles), Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure), Bronchitis (inflammation of the mucous membrane in the bronchial tubes), Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving), Coronary artery occlusion (complete obstruction of blood flow in a coronary artery), Dehydration (dryness resulting from the removal of water), Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall), Fainting (loss of consciousness and postural tone), Fibromyalgia (a long-term condition which causes pain all over the body), Flatulence (flatus expelled through the anus), Fluid retention (an abnormal accumulation of fluid in the blood), Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus), Gastrointestinal disorder (functional problems of gastrointestinal tract), Gout (uric acid crystals building up in the body), Heart palpitations (feelings or sensations that your heart is pounding or racing), Hyperhidrosis (abnormally increased sweating), Hypoaesthesia (reduced sense of touch or sensation), Hypotension (abnormally low blood pressure), Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone), Injection site erythema (redness at injection site), Injection site extravasation (flow of (blood or lymph) from injection site), Injection site haemorrhage (bleeding from injection site), Injection site pruritus (severe itching at injection site), Injection site urticaria (rash of round, red welts on the skin at injection site), Injection site vesicles (fluid- or air-filled cavity or sac at injection site), Low density lipoprotein decreased (cholesterol decreased), Low density lipoprotein increased (cholesterol increased in blood), Lymph follicular hypertrophy (an increase in the size of the lymph node follicles), Malaise (a feeling of general discomfort or uneasiness), Mobility decreased (ability to move is reduced), Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves), Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves), Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves), Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves), Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels), Nasopharyngitis (inflammation of the nasopharynx), Nausea (feeling of having an urge to vomit), Neuropathy peripheral (surface nerve damage), Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect), Pollakiuria (abnormally frequent passage of relatively small quantities or urine), Pruritus generalised (generalized itching), Renal impairment (severely reduced kidney function), Respiratory disorder (respiratory disease), Respiratory tract congestion (blockage on respiratory system), Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve), Seasonal allergy (allergic condition due to certain season), Skin blushing/flushing (a sudden reddening of the face, neck), Skin exfoliation (removal of the oldest dead skin cells), Stroke (sudden death of a portion of the brain cells due to a lack of oxygen), The flu (the flu is caused by an influenza virus), Therapeutic response decreased (less preventive response), Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)), Tremor (trembling or shaking movements in one or more parts of your body), Urticaria (rash of round, red welts on the skin that itch intensely), Wheezing (a high-pitched whistling sound made while you breath), Type 2 diabetes in Pfizer BioNTech Covid Vaccine, Type 2 diabetes in Johnson and Johnson Covid Vaccine, Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension, Attention deficit disorder with hyperactivity (addh), Attention deficit hyperactivity disorder (adhd), Inflammatory bowel disease - crohn's disease, Sleep disorder due to a general medical condition, Sleep disorder due to general medical condition, insomnia type, Atacand and Postoperative Wound Infection, Tramadol and Darifenacin drug interaction, Levoxyl and Valacyclovir drug interaction, Muscle Aches (muscle pain): 7 people, 11.29%, Nausea (feeling of having an urge to vomit): 4 people, 6.45%, Liver Disorder (liver diseases): 3 people, 4.84%, Hypoacusis (loss of hearing): 3 people, 4.84%, Injection Site Bruising: 3 people, 4.84%, Hyperlipidaemia (presence of excess lipids in the blood): 15 people, 24.19%, Low Density Lipoprotein Increased (cholesterol increased in blood): 6 people, 9.68%, Metabolic Syndrome (a combination of the medical disorders that, when occurring together, increase the risk of developing cardiovascular disease): 1 person, 1.61%, Low Density Lipoprotein: 1 person, 1.61%, Hypertriglyceridaemia (excess of triglycerides in the blood): 1 person, 1.61%, Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 1.61%, Atherosclerosis (disorder of the arteries): 1 person, 1.61%. Some of. Studies have proved that this drug lowered cholesterol levels in some patients within 4 to 12 weeks. But keep in mind that fatigue can also be a symptom of rare but more serious side effects Repatha can cause, including diabetes or increased blood sugar levels. And it's expected to rack up blockbuster . 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